Maria’s early medical practice focused on psychiatry. She later developed an interest in education, attending classes on pedagogy and immersing herself in educational theory. Her studies led her to observe, and call into question, the prevailing methods of teaching children with intellectual and developmental disabilities.

The opportunity to improve on these methods came in 1900, when she was appointed co-director of a new training institute for special education teachers. Maria approached the task scientifically, carefully observing and experimenting to learn which teaching methods worked best. Many of the children made unexpected gains, and the program was proclaimed a success.

In 1907, Maria accepted a challenge to open a full-day childcare center in San Lorenzo, a poor inner-city district of Rome. The students were under-served youngsters, ages 3 – 7, who were left to their own devices while their parents went out to work. This center, the first of its kind in the nation, and a high-quality learning environment, became the first Casa dei Bambini.

The children were unruly at first, but soon showed great interest in working with puzzles, learning to prepare meals, and manipulating learning materials Maria had designed. She observed how the children absorbed knowledge from their surroundings, essentially teaching themselves.

Using scientific observation and experience gained from her earlier work with young children, Maria designed learning materials and a classroom environment that fostered the children’s natural desire to learn and provided freedom for them to choose their own materials.